Figure 4.

Joint assessment of MIS and clinical variables. (A) Forest plot representing HR of Cox multivariable model obtained by backward selection. (B) Forest plot representing HR of Cox multivariable model of the clinical variables without MIS. (C) Forest plot representing HR of Cox multivariable model of the clinical variables with MIS. The categorical variables gender, tumor burden, pretreatment, therapy and stage were modeled as such, while age, log(LDH) and NLR were linearly modeled as continuous variables. HR estimates were referred to the corresponding IQR. BRAFi, BRAF inhibitors; ICI, immune checkpoint inhibitors; LCL, lower confidence limit; log(LDH), log-transformed lactate dehydrogenase; MEKi, MEK inhibitor; MIS, myeloid index score; UCL, upper confidence limit; NLR, neutrophil-to-lymphocyte ratio.