Figure 4.

Microchannels for studying cancer cell migration under confinement

(A) Microfluidic channels with different sized constrictions for studying nuclear deformation during confined migration. (Reproduced with permission from (Denais et al., 2016)).

(B) PDMS ceiling with short supporting pillars can create a controllable confined microenvironment for studying the effects of varying degrees of confinement on cancer cells. (Reproduced with permission from (Liu et al., 2015)).

(C) Y-shape microfluidic channel with different sized openings for comparing the metastastic ability of cancer cells. (Reproduced with permission from (Yankaskas et al., 2019)).

(D) Transwell membrane inserts for studying cancer cell transmigration through small pores with defined diameters.