Figure 6.

In vitro perfusion assays mimicking blood circulation for metastasis studies

(A) Microfluidic constricted channels for quantifying cancer cell deformability in a microcirculation mimicking condition. (Reproduced with permission from (Hou et al., 2009)).

(B) Microfluidic constricted channels with different geometries for studying the influence of intravascular deformation on CTCs. (Reproduced with permission from (Cognart et al., 2020)).

(C) In vitro microcirculation-on-a-chip microfluidic device for studying cancer cell behavior in capillaries under flow condition. (Reproduced with permission from (Chen et al., 2017))