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. 2021 Feb 17;19:79. doi: 10.1186/s12967-021-02744-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Correlations among lymph/monocytes count, D-dimer, and iron status affect the systemic response to SARS-CoV-2 infection. a Left: correlation plot of all variables [including derivative variables such as iron to ferritin ratio (IFR), neutrophils to lymphocytes ratio (NLR), platelets to lymphocytes ratio (PLR), monocytes to lymphocytes ratio (MLR)] to identify potential inter-variables correlations. The colour represents the direction of the correlation. Only boxes showing a significant correlation have been coloured; right, network plot showing direction and distribution of correlations between variables. Clusters of variables belonging to similar functions have been grouped. b Scatter plot representing the correlation between lymphocytes and monocytes. Remarkably, almost all the deaths are localized within the lower left quadrant of the plot. c Scatter plot showing the association between IL-6 and IFR. This correlation reaches statistical significance within the intermediate group only, further supporting the discriminating role of IFR within this subgroup