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Schematic showing how ICAM‐1 activated by platelets increases endothelial permeability after insufficient RFA. ICAM‐1 in TAECs after insufficient RFA induces platelet aggregation and activation, increases endothelial permeability through Ezrin/VE‐cadherin, and facilitates tumor transendothelial migration. R300 is used for platelet deletion and anti‐ICAM‐1 antibody is used for blockade of ICAM‐1 for potential therapy.
