Table 2. The antioxidant and oxidant parameter levels of liver tissue in experimental groups.
| Groups | Parameters | ||||
|---|---|---|---|---|---|
| SOD | GSH | CAT | MDA | MPO | |
| Control | 3.68 ± 0.16 | 15.25 ± 0.87 | 7.06 ± 1.05 | 103.33 ± 1.73 | 76.94 ± 5.59 |
| APAP | 1.40 ± 0.12a | 3.94 ± 0.79a | 4.62 ± 0.42c | 134.25 ± 3.66a | 115.28 ± 15.47c |
| FA | 2.01 ± 0.09a,** | 18.05 ± 2.57*** | 8.51 ± 0.49*** | 106.39 ± 2.74*** | 62.09 ± 3.62c, *** |
| APAP+FA | 5.00 ± 0.19a, *** | 13.72 ± 0.94*** | 7.32 ± 0.89* | 113.51 ± 3.64c, ** | 102.98 ± 7.76c |
| APAP+NAC | 5.05 ± 0.14a, *** | 14.72 ± 0.86*** | 8.15 ± 1.23** | 91.62 ± 2.84b, *** | 82.87 ± 5.21 |
| P | 0.001 | 0.001 | 0.026 | 0.001 | 0.001 |
APAP: acetaminophen, FA: folic acid, APAP+FA: acetaminophen+ folic acid, APAP+NAC: acetaminophen+ N-acetylcysteine. SOD (Superoxide dismutase, U/mg protein), GSH (Reduced glutathione, mg/g protein), CAT (Catalase, k/mg protein), MDA (Malondialdehyde, nmol/mg protein), MPO (Myeloperoxidase, mmol/min/mg protein). a: P<0.001, b: P<0.01 and c: P<0.05 significantly different from control group. ***: P<0.001, **: P<0.01 and *: P<0.05 significantly different from APAP group (Bonferroni test).