Table 3. The antioxidant and oxidant parameter levels of kidney tissue in experimental groups.
| Groups | Parameters | ||||
|---|---|---|---|---|---|
| SOD | GSH | CAT | MDA | MPO | |
| Control | 5.77 ± 0.15 | 13.74 ± 0.53 | 2.12 ± 0.17 | 88.60 ± 5.03 | 40.37 ± 1.57 |
| APAP | 4.59 ± 0.08a | 3.85 ± 0.48a | 0.97 ± 0.06b | 138.46 ± 7.04a | 61.19 ± 6.26c |
| FA | 7.59 ± 0.26 a, *** | 12.38 ± 1.06*** | 4.91 ± 1.02b, *** | 94.69 ± 5.70*** | 31.50 ± 2.09b, *** |
| APAP+FA | 6.23 ± 0.22*** | 6.35 ± 0.58a, * | 2.90 ± 0.26*** | 111.53 ± 2.91a, ** | 31.29 ± 2.33b, *** |
| APAP+NAC | 5.22 ± 0.16b, ** | 9.67 ± 0.81a, *** | 2.95 ± 0.26c, *** | 90.83 ± 2.28*** | 34.60 ± 4.01c, *** |
| P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 |
APAP: acetaminophen, FA: folic acid, APAP+FA: acetaminophen+ folic acid, APAP+NAC: acetaminophen+ N-acetylcysteine. SOD (Superoxide dismutase, U/mg protein), GSH (Reduced glutathione, mg/g protein), CAT (Catalase, k/mg protein), MDA (Malondialdehyde, nmol/mg protein), MPO (Myeloperoxidase, mmol/min/mg protein). a: P<0.001, b: P<0.01 and c: P<0.05 significantly different from control group. ***: P<0.001, **: P<0.01 and *: P<0.05 significantly different from APAP group (Bonferroni test).