Table 4. Effect of FA on the histological lesions induced by treatment of rats with APAP.
| Tissue | Groups | |||||
|---|---|---|---|---|---|---|
| Control | APAP | FA | APAP+FA | APAP+NAC | ||
| Liver | Disruption in the structure of hepatic cords | - | ++++ | + | ++ | ++ |
| Enlargement of the central veins | - | ++++ | + | ++ | ++ | |
| Edema | - | ++++ | + | ++ | ++ | |
| Hemorrhage | - | ++++ | + | ++ | ++ | |
| Necrosis | - | ++++ | - | ++ | + | |
| Vacuolar degeneration | - | +++ | + | ++ | ++ | |
| Glycogen storage ability | ++++ | - | ++ | ++ | ++ | |
| Kidney | Congestion | - | +++ | + | ++ | + |
| Tubular dilatation | - | +++ | + | ++ | + | |
| Enlarged Bowman spacing | - | +++ | + | ++ | + | |
| Tubular necrosis/degeneration | - | +++ | - | + | + | |
APAP: acetaminophen, FA: folic acid, APAP+FA: acetaminophen+folic acid, APAP+NAC: acetaminophen+N-acetylcysteine. (−): no pathological change, (+): mild (++): moderate, (+++): severe, (++++): very severe.