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. 2021 Feb 11;17:1744806921992187. doi: 10.1177/1744806921992187

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© The Author(s) 2021

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — The effects of NPW30 microinjected into the ipsilateral LC decreased the phase 1 (p < 0.005) and phase 2 (p < 0.001) responses. IP naloxone, IT idazoxan, IT WAY100135 antagonized the phase 2 depressant effect of NPW30. IT idazoxan significantly enhanced the phase 1 analgesic effect of NPW30 and antagonized the phase 2 effect. IT prazosin and IT SB269970 significantly enhanced the phase 2 analgesic effect of NPW30. Ordinate: number of flinches per min; abscissa: time after drug administration (min).