Table 3.
Predictors of CA125 and CA15.3 by race/ethnicity using stepwise regression
| Alla,b | Non-Hispanic white | Non-Hispanic black | Mexican American | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Predictors | Average % differences (95%CI) | p-value | Predictors | Average % differences (95%CI) | p-value | Predictors | Average % differences (95%CI) | p-value | Predictors | Average % differences (95%CI) | p-value |
| Non-Hispanic white | ref | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| Non-Hispanic black | −27.1 (−38.9, −12.9) | 0.002 | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Mexican American | −3.9 (−14.3, 7.8) | 0.47 | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Age, years | 1.0 (0.6, 1.4) | <.0001 | Age, years | 1.1 (0.7, 1.5) | <.0001 | -- | -- | -- | -- | -- | -- |
| Tubal ligation | 10.3 (−0.8, 22.7) | 0.07 | Tubal ligation | 13.5 (2.1, 26.3) | 0.02 | -- | -- | -- | Tubal ligation | −14.6 (−27.7, 0.8) | 0.06 |
| Hysterectomy | −24.6 (−44.2, 1.9) | 0.06 | Hysterectomy | −12.7 (−23.8, 0.03) | 0.05 | Hysterectomy | −17.8 (−34.4, 2.9) | 0.08 | -- | -- | -- |
| Previous history of cancer | 9.6 (−4.9, 26.3) | 0.19 | Previous history of cancer | 11.6 (−4.1, 29.8) | 0.14 | Age at menarche, years | 4.7 (−0.5, 10.1) | 0.07 | -- | -- | -- |
| Age at natural menopause, years | -- | -- | -- | Smoking status, never | ref | Smoking status, never | ref | ||||
| <46 | ref | -- | -- | -- | Smoking status, former | −0.4 (−12.1, 12.7) | 0.94 | Smoking status, former | 9.7 (−5.1, 26.8) | 0.19 | |
| 46–49 | 3.0 (−18.1, 29.5) | 0.79 | -- | -- | -- | Smoking status, current | −25.8 (−54.0, 19.6) | 0.20 | Smoking status, current | −25.6 (−50.5, 11.7) | 0.14 |
| 50–52 | 16.0 (−6.1, 43.2) | 0.16 | -- | -- | -- | -- | -- | -- | Parous | −20.9 (−40.3, 4.7) | 0.09 |
| 52≤ | 8.9 (−12.1, 34.8) | 0.41 | -- | -- | -- | -- | -- | -- | Duration of OC use, months | 0.4 (0.1, 0.6) | 0.005 |
| Missingd | 27.6 (−6.5, 74.3) | 0.12 | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Alla,c | Non-Hispanic white | Non-Hispanic black | Mexican American | ||||||||
| Predictors | Average % differences (95%CI) | p-value | Predictors | Average % differences (95%CI) | p-value | Predictors | Average % differences (95%CI) | p-value | Predictors | Average % differences (95%CI) | p-value |
| Non-Hispanic white | ref | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| Non-Hispanic black | 14.2 (−1.2, 32.0) | 0.07 | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Mexican American | −3.7 (−20.6, 16.8) | 0.68 | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Age, years | −0.3 (−0.8, 0.1) | 0.13 | Age, years | −0.3 (−0.9, 0.2) | 0.2 | -- | -- | -- | Age, years | −1.4 (−3.4, 0.6) | 0.16 |
| Duration of OC use, months | −0.1 (−0.2, −0.1) | 0.002 | Duration of OC use, months | −0.2 (−0.2, −0.1) | 0.003 | -- | -- | -- | Duration of OC use, months | −0.4 (−0.7, 0.01) | 0.06 |
| Age at natural menopause, years | -- | -- | -- | HT use, never | ref | -- | -- | -- | |||
| <46 | ref | -- | -- | -- | HT use, former | 20.0 (−17.4, 74.4) | 0.32 | -- | -- | -- | |
| 46–49 | −15.4 (−30.0, 2.2) | 0.08 | -- | -- | -- | HT use, current | −18.6 (−34.5, 1.1) | 0.06 | -- | -- | -- |
| 50–52 | −9.8 (−28.3, 13.4) | 0.35 | -- | -- | -- | -- | -- | -- | Ever breastfeeding | −17.1 (−37.7, 10.3) | 0.18 |
| 52≤ | −19.1 (−32.6, −3.0) | 0.03 | -- | -- | -- | -- | -- | -- | Previous history of cancer | 40.1 (5.7, 85.5) | 0.02 |
| Missingd | −15.1 (−29.4, 2.1) | 0.08 | -- | -- | -- | -- | -- | -- | -- | -- | -- |
a
Race was forced in the model
b
Women missing data on candidate predictors for CA125 were excluded: smoking status (n=2), age at menarche (n=35), duration of oral contraceptive (OC) use (n=9), parous (n=1), tubal ligation (n=8), hysterectomy (n=3), hormone therapy (HT)use (n=36)
c
Women missing data on candidate predictors for CA15.3 were excluded: smoking status (n=2), duration of oral contraceptive (OC) use (n=9), breastfeeding (n=1), hysterectomy (n=3), hormone therapy (HT) use (n=36)
d
96% had surgical menopause