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. 2021 Jan 22;206(5):953–962. doi: 10.4049/jimmunol.2000036

FIGURE 5.

FIGURE 5.

SZB120 inhibits Th17 development in the mouse model of EAE. (A) Schematic diagram of the EAE model. (B) Clinical score of the mice with EAE treated with 20 mg/kg/d SZB120 and an equivalent volume of DMSO (n = 4). (C) Representative images of H&E staining and Luxol fast blue staining of paraffin-embedded sections of spinal cords isolated from the DMSO- or SZB120-treated EAE model on day 15 postimmunization. Scale bar, 30 μm. Quantification of CNS infiltrates and the amount of demyelination are shown in the right panel. (D and E) Flow cytometric analysis of Th17 cells, Th1 cells, and regulatory cells percentages gated on CD4+ T cells, which were taken from the CNS or lymph node samples of the DMSO- or SZB120-treated mouse model of EAE on day 15 after immunization (n = 4, 5). Data are the mean ± SEM. *p < 0.05, ***p < 0.001.