FIGURE 6.

SZB120 represses IMQ-induced skin inflammation in mice. (A and B) The percentage of CD4⁺ IL-17⁺ splenocytes and ear dermis cells was measured (n = 3). (C) The percentage of CD11b⁺Ly-6G⁺ cells in each group was measured (n = 3). (D) The percentage of γδT⁺IL-17⁺ cells in ear dermis cells was measured (n = 3), and CD3⁺ cells were gated. (E) Representative phenotypes of the vehicle-, solvent control-, and SZB120-treated mice. The experiment was repeated three times independently. (F) Skin thickness was measured on the seventh day and compared with DMSO (n = 3–6). (G) Representative H&E staining of every group. Scale bar, 50 μm. (H) Acanthosis and dermal cellular infiltrate of skin samples of every group (n = 3–5). Data are the mean ± SEM by unpaired t test (A–C) and one-way ANOVA (D, F, and H). *p < 0.05, **p < 0.01, ***p < 0.001.