| EGCG |
TgCRND8 mice |
soluble
Aβ |
improved learning and memory |
(264) |
| |
SAMP8 mice |
Aβ1–42, BACE-1,
tau, |
rescued spatial learning |
(265) |
| |
APPsw mice |
Aβ1–42, tau |
cognitive benefits |
(266) |
| |
CUMS rats |
Aβ1–42, mTOR, p70S6K |
enhanced spatial learning and memory |
(267) |
| anthocyanins |
APdE9 mice |
APP processing |
alleviated behavioral and memory deficits |
(268) |
| curcumin |
THP-1 cells |
Egr1, TNFα, IL1β, MAPK |
ameliorate inflammation |
(269) |
| |
PC12
cells |
Aβ42 |
protection from Aβ
insult |
(270) |
| nobiletin |
APP-SL7–5 mice |
Aβ42, ERK |
improves memory impairment |
(271) |
| |
3xTg-AD |
Aβ1–40, ROS |
reversal of impaired learning and memory |
(272) |
| |
SAMP8 mice |
p-tau, SOD1,
GPx |
ameliorates learning and memory deficits |
(273) |
| |
AD rats |
Aβ42,
PKA, CREB |
rescues memory deterioration |
(274) |
| resveratrol |
AD patients |
Aβ40,
MMP9, IL-4, FGF-2 |
inhibits
inflammation and cognitive decline |
(275) |
| baicalein |
Tg2576 mice |
APP |
improved cognitive performance |
(276) |
| myricetin |
AD rats |
AMPK, SIRT1 |
suppresses apoptosis, improves learning |
(277) |
| quercetin |
3xTg-AD |
Aβ42, tau |
improves learning performance |
(278) |
| |
3xTg-AD |
Aβ42, BACE1 |
strengthens spatial memory |
(279) |
| kaempferol |
AD rats |
SOD, GSH, TNFα, MDA |
improves spatial learning and memory |
(280) |
| silibinin |
Aβ treated rats |
BDNF/TrkB,
autophagy |
ameliorates anxiety/depression behaviors |
(281) |
| apigenin |
APP/PS1 mice |
APP, BACE1, SOD1, GPx |
relieves learning and memory
impairment |
(282) |
| rutin |
rat model |
ERK1, CREB, and BDNF |
rescues amyloid induced
neurotoxicity |
(283) |
| wogonin |
3xTg-AD
mice |
APP, tau, cleaved PARP |
enhances neurite
outgrowth and memory |
(284) |
| |
SH-SY5Y
cells |
APP, tau, mTOR |
may improve cognitive
function |
(285) |
| fisetin |
2x FAD mice |
Cdk5, ERK |
improves learning and memory deficits |
(286) |
| |
SAMP8 mice |
Arc, GFAP,
p35, SAPK/JNK |
delays aging and cognitive decline |
(287) |
| catechin |
PC12 cells |
Aβ |
reduces apoptosis and neurotoxicity |
(288) |
| 7,8-DHF |
5xFAD |
BACE1,
Aβ, TrkB |
attenuates memory deficit |
(289) |
| |
5xFAD |
TrkB |
restores
synapses and memory |
(290) |
| morin |
3xTg-AD mice |
GSK3β, tau, Aβ |
increased neuroprotection |
(291) |
| luteolin |
Tg2576 mice |
GSK3β, PS1, Aβ |
reduces Aβ toxicity |
(292) |
| diosmin |
Tg2576 mice |
Aβ42 |
reduces Aβ
toxicity |
(292) |
| |
3xTg-AD mice |
Aβ42, tau |
suppresses inflammation and memory
loss |
(293) |
| diosmetin |
3xTg-AD mice |
GSK3β, γ-secretase |
reduces inflammation
and cognitive loss |
(293) |
| hesperetin |
Neuro-2A cells |
IR, Akt, GLUT3, GLUT4 |
regulates autophagy and metabolism |
(294) |
| hesperidin |
Neuro-2A cells |
IR, Akt, GLUT3,
GLUT4 |
regulates autophagy and metabolism |
(294) |
| |
APP/PS1 mice |
iNOS, TNFα,
IL1β |
restores behavioral/social interaction |
(295) |
| puerarin |
SAD mice |
GPx,
SOD, MDA |
regulates oxidative stress/memory decline |
(296) |
| |
SAD mice |
caspase-3, p38, JNK, Bax |
reduces oxidative
damage and apoptosis |
(297) |
| |
APP/PS1
mice |
Nrf2, HO1, Akt, GSK-3β |
alleviates
cognitive impairment |
(298) |
| naringenin |
rat model |
GSK-3, PPARγ, IR, Tau, Aβ42 |
facilitates spatial learning and memory |
(299) |
| naringin |
AD rats |
Ach, IL1β, mitochondria |
mitigates cognitive decline |
(300) |
| genistein |
SAD rats |
APP, Aβ42, tau |
restores autophagy, behavioral normalcy |
(301) |
