| Liposomes |
| baicalein |
SHSY5Y,
PC12 cells |
slow release, high internalization |
protects against oxidative stress |
(205) |
| resveratrol |
NIH-3T3 |
improved solubility |
presents no cytotoxicity |
(302) |
| quercetin |
rat model |
enhanced solubility |
anxiolytic and cognitive benefits |
(303) |
| |
SK-N-MC cells |
enhanced access through
BBB |
suppression of neuronal apoptosis |
(201) |
| EGCG |
N2a cells, rats |
increased
oral bioavailability |
enhances α-secretase activity |
(304) |
| Silica Nanoparticles |
| catechin |
hippocampal cells |
high solubility |
enhances cell survival |
(305) |
| chrysin |
hippocampal cells |
improved drug entrapment |
suppresses Aβ toxicity |
(306) |
| quercetin |
hippocampal cells |
retains physicochemical
integrity |
improves antioxidant activity |
(307) |
| naringin |
hippocampal cells |
entraps
higher drug doses |
reduces Aβ toxicity |
(231) |
| Selenium NPs |
| EGCG |
PC-12 cells |
high affinity for Aβ |
disaggregates Aβ
fibrils |
(206) |
| curcumin |
5x FAD mice |
increased binding with plaques |
inhibits Aβ
aggregation |
(308) |
| Polymeric NPs |
| EGCG |
APP/PS1 mice |
increases drug stability |
increased synapses |
(309) |
| EGCG |
rats |
superior bioavailability of drug |
improves neurobehavioral deficits |
(310) |
| anthocyanin |
SH-SY5Y cells |
slow and sustained
drug release |
abrogates oxidative stress |
(243) |
| quercetin |
SH-SY5Y cells |
sustainable
release |
disassembles Aβ fibrils |
(311) |
| curcumin |
SK-N-SH cells |
increased
solubility and stability |
suppresses ROS and Nrf2 |
(312) |
| Lipid Core Nanocapsules |
| resveratrol |
hippocampal cultures |
restricts drug photosenstivity |
reduces Aβ induced inflammation |
(313) |
| Protein Nanoparticles |
| quercetin |
SAMP8 mice |
greater bioavailability |
improved
cognition and memory |
(255) |
| Solid Lipid Nanoparticles |
| curcumin |
5× FAD mice |
enhanced affinity to Aβ-plaques |
may interfere
with Aβ fibrillation |
(212) |
| resveratrol |
in vitro BBB model |
enhanced cellular uptake |
inhibits amyloid beta aggregation |
(314) |
| chrysin |
rats |
improved bioavailability |
mitigates Aβ induced stress |
(315) |
| quercetin |
rats |
higher drug entrapment |
improved memory retention |
(249) |
| |
Danio rerio |
improved
drug release |
attenuates cognitive impairments |
(316) |
| Nanostructured
Lipid Carriers |
| baicalein |
rat
model |
higher drug accumulation |
superior
brain targeting |
(317) |
| quercetin |
Caco-2 cells |
increased drug residence |
improved stress resistance |
(318) |
| Metal Nanoparticles |
| curcumin |
Tg2576 mice |
enhanced affinity to Aβ-plaques |
may interfere with Aβ fibrillation |
(319) |
| |
neuro2a cells |
high solubility and Aβ
affinity |
dissolves amyloid fibrils |
(320) |
| anthocyanins |
AD mice model |
better release
and bioavailability |
inhibits neuronal apoptosis |
(204) |
| |
AD mice model |
instability,
bioavailability |
lowers Aβ induced inflammation |
(321) |
| quercetin |
rat model |
high plasma concentration |
prevent neural cell apoptosis |
(227) |
| |
SH-SY5Y cells |
high
BBB permeability |
enhances autophagy clearance |
(322) |
