Table 4. Spontaneous Resistant Mutants Raised against P19 and Their Corresponding MICs.

			SNPs identified in P19 resistant mutants in rv1751 (# of independent mutants isolated)
Cpd	MIC (μM)	WT	L399W (7)	V96L (6)	H97Y/N (2)	L250Q (2)	P152S (1)	A434T (1)
P19	MIC	0.78	12.5	2.3	1.56	2.3	1.56	1.56
	fold change		16	3	2	3	2	2
P24	MIC	1.56	18.8	7.82	6.25	6.26	3.90	3.12
	fold change		12	5	4	4	2.5	2
1	MIC	1.2	12.5	2.3	1.56	3.13	2.3	1.56
	fold change		10	2	1.3	2.6	2	1.3
2	MIC	0.39	0.39	1.2	0.39	1.2	1.2	1.2
	fold change		1	3	1	3	3	3
4	MIC	1.56	3.13	2.3	1.56	4.7	2.3	2.3
	fold change		2	1.5	1	3	1.5	1.5
INH	MIC	0.04	0.04	0.04	0.04	0.04	0.04	0.04