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. Author manuscript; available in PMC: 2021 Feb 17.
Published in final edited form as: ACS Chem Biol. 2020 Apr 3;15(5):1261–1267. doi: 10.1021/acschembio.0c00002

Figure 1.

Figure 1.

Crosslinking reaction by TPs. (a) Example of two binding sites (acyl-donor and -acceptor) at the intermediate step of the crosslinking reaction are depicted. The acyl-chain is covalently anchored on the TP, which is subsequently transferred to the amino group on the acyl-acceptor strand. X represents the crossbridging amino acids. (b) Schematic of PG crosslinking in E. faecium showing the 2 types of crosslinks observed.