Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 16;21:60. doi: 10.1186/s12890-021-01420-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — PFKFB4 promoted lung adenocarcinoma cells proliferation, migration and invasion via phosphorylating SRC-2 at Ser487. a, b A549 and NCI-H1975 were treated with DMSO or 10 μM 5MPN and/or transfected with pCMV vector and/or SRC-2 WT/S487A. The expression of PFKFB4, SRC-2 and CARM1 at protein level was examined by western blot. c, d CCK-8 assay was performed among A549 and NCI-H1975 treated with DMSO or 10 μM 5MPN and/or transfected with pCMV vector and/or SRC-2 WT/S487A. All experiments are performed in triple. e, f Transwell and Transwell-matrigel assay were performed among A549 and NCI-H1975 treated with DMSO or 10 μM 5MPN and/or transfected with pCMV vector and/or SRC-2 WT/S487A, respectively. Representative images are captured with the magnification of × 200. **P < 0.01. All experiments are performed in triple