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. 2021 Feb 17;19:39. doi: 10.1186/s12916-021-01917-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Transferrin serum levels reflect the decreased transferrin expression in advanced liver disease. a, b Hepatic transferrin protein levels were determined by immunoblotting in cirrhotic patients (cirrhosis) and individuals without a significant liver disease (control). GAPDH was used as a loading control. The relative band intensity was quantified with the ImageJ software (cohort i). c Immunohistochemical staining of liver sections with an antibody against transferrin. Scale bar = 200 μm (cohort i). d Normalized transcripts per million base pairs (tpm) of the Transferrin gene in patients with alcohol-related liver disease and normal livers. The samples were obtained from biopsies from patients with normal background liver (“Normal,” N = 10), patients with early or silent alcohol-related steatohepatitis (“Early,” N = 12), and patients with alcoholic hepatitis (AH), at different disease stages: non-severe (NSev_AH, N = 11) and severe (Severe_AH, N = 27, including biopsies N = 18 and explants N = 9) (cohort ii). e Spearman’s correlation coefficient reveals the relationship between serum transferrin levels and relative hepatic transferrin mRNA expression in 23 patients with advanced liver disease and available matched serum-mRNA sample pairs (cohort i)