Table 5.
Notable changes of biological parameters in mice after treatment with TiO2 and LPS
| Group | 1 month | 3 months | 6 months |
|---|---|---|---|
| L |
Duodenal villi height/ crypt depth ratio ↑ Ileal villi height/ crypt depth ratio ↓ Ileal IL-1β ↓ |
Duodenal villi height/ crypt depth ratio ↓ |
Duodenal villi height/ crypt depth ratio ↓ Serum DAO ↓ Serum TNF-α ↑ |
| NP |
Duodenal villi height/ crypt depth ratio ↑ Ileal villi height/ crypt depth ratio ↓ Ileal Occludin ↑ |
Ileal villi height/ crypt depth ratio ↑ |
Food intake ↓ Serum IL-1β ↓ |
| NP+L |
Jejunal villi height/ crypt depth ratio ↑ Ileal ZO-1 ↑ |
Jejunal villi height/ crypt depth ratio ↑ Serum DAO ↓ |
Serum DAO ↓ Ileal IL-1β ↓ |
| MP |
Duodenal villi height/ crypt depth ratio ↑ Jejunal villi height/ crypt depth ratio ↑ Ileal ZO-1 ↑ |
Jejunal villi height/ crypt depth ratio ↑ Ileal villi height/ crypt depth ratio ↑ Serum IL-1β ↓ |
Ileal microvilli ↓, Blood Ti ↑ Serum IL-6 ↓ |
| MP+L |
Ileal villi height/ crypt depth ratio ↓ Ileal ZO-1 ↑ |
Serum LPS ↓, Serum DAO ↓ | Ileal ZO-1 ↑ |