Table 4. Pharmacokinetic Parameters of Oleoglycine and Tyrosol Acetate Following a Single Intravenous Administration of 30 mg/kg Oleocanthal to Mice (n = 3 per Three Time Points).
| |
oleoglycine |
tyrosol
acetate |
|||
|---|---|---|---|---|---|
| parameter | unit | 37 °C | 60 °C | 37 °C | 60 °C |
| Cmax(@5min) | μg/mL | 29.0 ± 4.4 | 231.6 ± 70.8 | 42.5 ± 4.5 | 191.4 ± 26.6 |
| t1/2 | h | 1.9 ± 0.3 | 3.2 ± 1.2 | 1.8 ± 0.8 | 7.5 ± 1.6 |
| AUC0-t | mg–h/L | 13.6 ± 1.3 | 93.6 ± 27.1 | 14.9 ± 5.7 | 48.8 ± 4.1 |
| kel | h–1 | 0.366 ± 0.07 | 0.242 ± 0.11 | 0.424 ± 0.15 | 0.095 ± 0.02 |
| CL | L/h | 2.2 ± 0.2 | 0.34 ± 0.1 | 2.2 ± 0.8 | 0.62 ± 0.05 |