. 2020 Dec 4;4(1):266–275. doi: 10.1021/acsptsci.0c00184

Table 1. Solvent Effects on the Coupling of 2-Deoxy-2-[¹⁸F]fluoro-1,3,5-tri-O-benzoyl-d-arabinofuranose (¹⁸F-Labeled Sugar) and O,O′-Bis(trimethylsilyl)thymine in the Radiosynthesis of [¹⁸F]FMAU (β-anomer).

solvent	polarity	class of residual solvents^a	concentration limit (ppm)^a	toxicity	% yield of β-anomer^b	ratio of anomers (β/α)
DMSO	polar	3	5000	low	ND^c	ND
DMF	polar	2	880	moderate	ND	ND
THF	polar	2	720	moderate	5.37	2.86
DCE	nonpolar	1	5	high	32.68	1.24
1,4-dioxane	nonpolar	2	380	moderate	48.07	1.06

Data are cited from the United States Pharmacopeia (USP) General Chapter ⟨467⟩ Residual Solvents, Rev. 20190927.

Radiochemical yields (%) are reported based on analytical HPLC.

ND; not detected.

Table 1. Solvent Effects on the Coupling of 2-Deoxy-2-[18F]fluoro-1,3,5-tri-O-benzoyl-d-arabinofuranose (18F-Labeled Sugar) and O,O′-Bis(trimethylsilyl)thymine in the Radiosynthesis of [18F]FMAU (β-anomer).