Table 2. Radiochemical Yield (%) and Analytical HPLC Retention Time of Crude and Final Product in the Radiosynthesis of [18F]FAU, [18F]FMAU, [18F]FEAU, [18F]FFAU, [18F]FCAU, [18F]FBAU, and [18F]FIAU Using 1,4-Dioxane as the Solvent.
| HPLC retention
time (min) |
||||||
|---|---|---|---|---|---|---|
| % radiochemical yielda |
crude
product |
final product | ||||
| radiotracer | α-anomer | β-anomer | ratio of anomers (β/α) | α-anomer | β-anomer | β-anomer |
| [18F]FAU | 51.41 | 48.59 | 0.95 | 5.05 | 5.68 | 5.60 |
| [18F]FMAU | 44.34 | 55.66 | 1.26 | 7.44 | 8.93 | 9.10 |
| [18F]FEAU | 52.12 | 40.78 | 0.78 | 16.11 | 20.14 | 20.30 |
| [18F]FFAU | 44.08 | 54.82 | 1.24 | 6.07 | 7.27 | 7.23 |
| [18F]FCAU | 37.95 | 57.53 | 1.52 | 8.81 | 11.10 | 11.12 |
| [18F]FBAU | 39.44 | 55.69 | 1.41 | 10.19 | 12.88 | 13.11 |
| [18F]FIAU | 37.67 | 54.78 | 1.45 | 13.67 | 17.13 | 17.53 |
a
Radiochemical yield (%) is reported based on analytical HPLC.