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. 2021 Feb 2;4(1):372–385. doi: 10.1021/acsptsci.0c00217

Figure 7.

Figure 7

Calpain inhibitors reverse or attenuate loss of proteins linked to BBB dysfunction and block proteolysis of spectrin and GFAP after neurotrauma. Quantitative analysis of immunoblots of ipsilateral hemispheres of WT and ALDH2–/– mice 24 h post-mTBI or null treatment, showing effect of calpain inhibitors (10 mg/kg i.p.), probed for ZO-1 (A), Occludin (B), Claudin-5 (C), MMP-9 (active/total, D), SBDP 145 kDaA (E), eNOS (F), GFAP (G), and GFAP-BDP (H). Data represents mean ± SD of n = 7–10 animals analyzed by one-way ANOVA with Dunnett’s or Tukey’s multicomparison analysis. All protein was normalized to the housekeeping protein, β-actin. 50 μg of protein was loaded in each well. *, p < 0.05; **, p < 0.01; and ***, p < 0.001 versus WT null control; #, p < 0.05; ##, p < 0.01; and ###, p < 0.001 versus ALDH2–/– + mTBI.