Table 1.
Comparison of Demographic and Clinical Characteristics of Hospitalized Patients Receiving Extended or Standard Infusion of Cefepime, Meropenem, or Piperacillin-Tazobactam
| Characteristics | Extended Infusion (n = 258) | Standard Infusion (n = 293) | p value |
|---|---|---|---|
| Sex, n (%), male | 147 (57) | 180 (61.4) | 0.288 |
| Age, median (IQR), yr | 7.2 (2.8–13.7) | 8.3 (3.1–13.0) | 0.597 |
| Duration of antibiotics, median (IQR), days | 5.9 (4.2–9.2) | 5.9 (4–8.8) | 0.91 |
| Dosing weight, median (IQR), kg | 23.6 (13–46.6) | 27.4 (14.5–50.1) | 0.105 |
| Received mechanical ventilation, n (%) | 52 (20.2) | 46 (15.7) | 0.172 |
| Received vasopressors, n (%) | 43 (16.7) | 33 (11.3) | 0.066 |
| Received ECMO support, n (%) | 12 (4.7) | 13 (4.4) | 0.904 |
| PRISM-3 Probability of death,19 median (IQR)* | 1.6 (0.6–5.1) | 1.3 (0.5–4.6) | 0.374 |
ECMO, extracorporeal membrane oxygenation; PRISM-3, pediatric risk of mortality-3
* Limited to patients in the PICU, extended (n = 48) and standard (n = 51).