Table 1.

The super-relaxed (SRX) state of myosin measured by mantATP/ATP chase assays in skinned papillary muscles from Tg-WT, Tg-A57G, and Tg-Δ43 mice. P1 and P2 represent fractions (in %) of myosin cross-bridges in the disordered relaxed (DRX) and SRX states, respectively, with fast T1 and slow T2 lifetimes. 1/T1 and 1/T2 represent the rates of ATP turnover in DRX and SRX states, respectively. Values are means T SD for n = # fibers.

Parameter	Tg-WT	Tg-A57G	Tg-Δ43
P1 (%)	59.33 ± 8.66	69.61 ± 8.51*,#	50.13 ± 10.25*
P2 (%)	37.60 ± 8.34	27.52 ± 8.67*,#	48.45 ± 9.21*
T1 (s)	6.25 ± 2.97	5.92 ± 3.94	4.23 ± 2.00
T2 (s)	117.70 ± 68.22	116.00 ± 80.89	193.40 ± 143.70
n = # fibers (#F and #M mice)	17 (5F and 3M)	13 (3F and 3M)	13 (4F and 5M)

^*P < 0.05 Tg-A57G/Tg-Δ43 versus Tg-WT.;

^#P < 0.05 Tg-A57G versus Tg-Δ43, one-way ANOVA with Tukey’s multiple comparison test.