Table 2.
Intact papillary muscle fiber studies on Tg-WT, Tg-A57G, and Tg-Δ43 mice. Force and calcium transients times (T) from peak force/[Ca2+] to 25, 50, and 75 percent of relaxation/baseline. Values are mean T SD for n = # animals.
| Tg-WT | Tg-A57G | Tg-Δ43 | |
|---|---|---|---|
| n = # animals (#F and #M mice) | 10 (3F and 7M) | 8 (3F and 5M) | 6 (3F and 3M) |
| Force transients | |||
| T25 relax (ms) | 55.9 ± 8.8 | 48.6 ± 5.2# | 61.8 ± 5.3 |
| T50 relax (ms) | 92.0 ± 15.9 | 78.1 ± 8.6# | 98.8 ± 11.0 |
| T75 relax (ms) | 137.2 ± 26.8 | 115.6 ± 17.3# | 148.3 ± 17.9 |
| Force/area (mNmm−2) | 0.38 ± 0.23 | 0.33 ± 0.22 | 0.24 ± 0.13 |
| [Ca2+] transients | |||
| T25 relax (ms) | 88.1 ± 13.5 | 107.4 ± 23.7 | 90.8 ± 17.8 |
| T50 relax (ms) | 148.2 ± 22.1 | 194.3 ± 41.7* | 154.7 ± 31.7 |
| T75 relax (ms) | 241.2 ± 18.0 | 320.0 ± 80.0* | 247.3 ± 52.3 |
*
P < 0.05 Tg-A57G versus Tg-WT.;
#
P < 0.05 Tg-A57G versus Tg-Δ43, one-way ANOVA with Tukey’s multiple comparison test.