Table 3.
Echocardiography assessment of heart morphology and function of Tg-WT, Tg-A57G, and Tg-Δ43 mice. Values are mean ± SD for n = # animals. d, diastole; e’, early diastolic mitral annulus velocity; EF%, ejection fraction; FS%, fractional shortening; HR, heart rate in beats per minute (bpm); IVCT, isovolumetric contraction time; IVRT, isovolumetric relaxation time; LVAW, left ventricular anterior wall; LVID, LV inner diameter; LVPW, LV posterior wall; MPI, myocardial performance index; MV E/A, mitral valve inflow—peak E (early)-wave-to-A (late)-wave velocity ratio; s, systole.
| Tg-WT | Tg-A57G | Tg-Δ43 | |
|---|---|---|---|
| n = # animals (# M and # F) | 9 (6M, 3F) | 9 (3M, 6F) | 9 (6M, 3F) |
| B- and M-modes | |||
| HR (bpm) | 477 ± 45 | 459 ± 61 | 444 ± 58 |
| EF (%) | 54 ± 3 | 55 ± 6 | 52 ± 3 |
| FS (%) | 31 ± 7 | 40 ± 14 | 42 ± 8 |
| LVAW;d (mm) | 0.96 ± 0.07 | 1.17 ± 0.11* | 1.10 ± 0.12* |
| LVAW;s (mm) | 1.43 ± 0.16 | 1.70 ± 0.22* | 1.59 ± 0.31 |
| LVID;d (mm) | 3.94 ± 0.56 | 3.66 ± 0.36 | 3.60 ± 0.44 |
| LVID;s (mm) | 2.74 ± 0.62 | 2.20 ± 0.66 | 2.27 ± 0.64 |
| LVPW;d (mm) | 1.00 ± 0.18 | 1.43 ± 0.40* | 1.51 ± 0.38* |
| LVPW;s (mm) | 1.32 ± 0.23 | 1.94 ± 0.47* | 1.88 ± 0.42* |
| LV mass/corr (mg) | 123 ± 28 | 168 ± 43 | 169 ± 52 |
| PW-Doppler and TDI | |||
| IVCT (ms) | 12.8 ± 2.33 | 14.2 ± 2.88 | 13.93 ± 3.70 |
| IVRT (ms) | 16.4 ± 2.73 | 22.9 ± 1.34*,# | 17.2 ± 1.15 |
| MV A (mm·s−1) | 449 ± 120 | 359 ± 180 | 431 ± 104 |
| MV E (mm·s−1) | 697 ± 160 | 571 ± 144 | 676 ± 153 |
| MV E/A | 1.44 ± 0.25 | 1.88 ± 0.75 | 1.57 ± 0.58 |
| MPI | 0.65 ± 0.13 | 0.80 ± 0.13*,# | 0.65 ± 0.11 |
| E/e’ | −24.2 ± 5.55 | −22.2 ± 6.65 | −27.1 ± 6.68 |
| e’ (mm·s−1) | −26.2 ± 6.65 | −28.0 ± 9.52 | −25.8 ± 6.14 |
*
P < 0.05 Tg-A57G/Tg-Δ43 versus Tg-WT.;
#
P < 0.05 Tg-A57G versus Tg-Δ43, one-way ANOVA with Tukey’s multiple comparison test.