Table 3.
Univariable and multivariable Cox regression analysis Overall Survival total group
| Univariable | Multivariable | |||
|---|---|---|---|---|
| Variable | Hazard Ratio [95% CI] | P-value | Hazard Ratio [95% CI] | P-value |
| Age at resection (cont.) | 1.013 [1.006-1.019] | <0.001* | 1.016 [1.008-1.023] | <0.001* |
| Node positive primary | 1.464 [1.245-1.721] | <0.001* | 1.455 [1.226-1.728] | <0.001* |
| DFI (cont.) | 1.001 [0.997-1.005] | 0.698 | 0.997 [0.993-1.002] | 0.221 |
| Number of CRLM (cont.) | 1.055 [1.022-1.089] | 0.001* | 1.078 [1.039-1.118] | <0.001* |
| Size CRLM (cont.) | 1.050 [1.027-1.074] | <0.001* | 1.063 [1.035-1.091] | <0.001* |
| Preoperative CEA (cont.) | 1.000 [1.000-1.000] | 0.483 | 1.000 [1.000-1.000] | 0.898 |
| Any perioperative systemic CTx without HAIP | 1.229 [1.056-1.430] | 0.008* | 0.788 [0.650-0.954] | 0.015* |
| Any perioperative HAIP CTx | 0.575 [0.460-0.719] | <0.001* | 0.542 [0.413-0.710] | <0.001* |
| R1 resection CRLM | 1.615 [1.316-1.981] | <0.001* | 1.409 [1.129-1.759] | 0.002* |
| Extrahepatic disease | 1.784 [1.448-2.196] | <0.001* | 1.731 [1.378-2.174] | <0.001* |
| Non-dHGP | 1.814 [1.480-2.223] | <0.001* | 1.569 [1.261-1.951] | <0.001* |
Abbreviations in alphabetical order: CEA: carcinoembryonic antigen; CI: confidence interval; CRLM: colorectal liver metastases; CTx: chemotherapy; DFI: disease free interval; HAIP: hepatic arterial infusion pump; HGP: histopathological growth pattern; non-dHGP: non-desmoplastic HGP; R1: positive resection margin
*
indicates significant P-value