Figure 5.
Transmission and buffering of metaplastic LTD require investigative behavior. A, Schematic showing 11 types of behaviors that include both social (approach, social grooming, chasing, sniffing, and attacking) and nonsocial behaviors (walking, self-grooming, digging, rearing, resting, and nesting). B, Pie chart analysis of social and nonsocial behaviors of mouse dyads in 30 min epochs in home cage. *p < 0.05 and *** p < 0.001 by χ2 test. C, Bar graph comparing the percentage of time spent in social grooming behavior toward stressed mice with or without LTD induction. D, Bar graph comparing the percentage of time engaged in anogenital sniffing behavior in naive partners with or without LTD induction. Data represent the mean ± SEM. Numbers in parenthesis represent animals examined. **p < 0.01, ***p < 0.001 compared with no LTD-expressing mice by two-tailed unpaired Student's t test.