Figure 6.

Direct behavioral contact is required for transmission and buffering of metaplastic LTD. A, Schematic showing the experimental design and timeline. In the experiment, the subject mouse was removed, exposed to a restraint–tailshock stress paradigm for 90 min, and then returned to its home cage with a perforated Plexiglas barrier to prevent direct behavioral contact for 30 min. B, Summary of experiments showing the induction of hippocampal CA1 LTD by LFS at Schaffer collateral–CA1 synapses in slices from stressed mice. C, Summary of experiments showing the induction of hippocampal CA1 LTD by LFS at Schaffer collateral–CA1 synapses in slices from naive partners. D, Bar graph comparing serum corticosterone levels in stressed mice and naive partners. E, Bar graph illustrating the proportion of individuals that express LTD or no LTD in stressed and naive partner groups. Representative traces of fEPSPs were taken at the time indicated by number. Dashed lines show the level of baseline. Data represent the mean ± SEM. ***p < 0.001 compared with LTD-expressing stress mice by two-tailed unpaired Student's t test.