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. 2021 Feb 10;41(6):1265–1273. doi: 10.1523/JNEUROSCI.2380-20.2020

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Copyright © 2021 Sun et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Within-animal changes in brain MOR availability as a function of daylength. A, B, Mean (with shaded area for 95% CI) time–activity curves for the reference region and the target regions (A) extracted using ROI template image overlaid on the PET and CT images (B). C, Ex vivo biodistribution of [¹¹C]carfentanil in brain regions of interests. D, Individual animals are shown as separate lines. Black dashed line shows the least-squares (LS) regression curve for the polynomial model (y ∼ x + x²) predicting BP_ND across the whole sample. Shaded area shows the 95% CI for the LS curve.