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. 2021 Feb 3;143(6):2464–2469. doi: 10.1021/jacs.0c12948

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Scheme 6 — Reagents and conditions: (a) MgBr₂·OEt₂, CH₂Cl₂, −78 °C, 88%; (b) TBSOTf, 2,6-lutidine, CH₂Cl₂, −78 °C, 64%; (c) Ph₃CK, PhNTf₂, THF, −78 °C; (d) (Bu₃Sn)₂CuCNLi₂, THF, −55 °C, 77% (isomer ratio ≈ 4:1); (e) 17, Pd(PPh₃)₄ (20 mol %), CuTC, [Bu₄N][Ph₂P(=O)O], NMP, 77% (pure isomer); HF·pyridine, THF/pyridine, 37%.