Table 2. SAR Analysis, Antibacterial Activity, and ADME Profiling of Sulfonamide Analogs^a.

no.	R	Lpd IC50 (μM)	Mtb MIC90 (μM)	Sol (μg/mL, pH 6.8)	hLM (μL/min/mg)	log D
2	a	0.104	>100	4.6	115	1.85
3	b	1.70	>100	0.15	113	1.94
4	c	0.11	>100	>110	2	1.69
5	d	0.128	>100	>120	15	2.12
6	e	0.056	>100	20	18	2.12
7	f	0.196	>100	>100	–14	1.37
8	g	0.331	>100	>97	6	1.32
9	h	2.75	>100	>95	–18	0.4
10	i	0.165	>100	>97	13	0.45
11	a	0.035	25	18	>768	2.26
12	e	0.029	12	23	195	2.55
13	i	0.045	3.1	>110	–11	0.83

^aIC₅₀ values were determined by the DTNB assay with 50 nM Lpd.