Table 1.
Effects of Ang-(1–12) on Steady-State Hemodynamics in Normal and after HF
| Control (n=10) | HF (n=16) | |||
|---|---|---|---|---|
| Baseline | Ang-(1–12) | Baseline | Ang-(1–12) | |
| Heart rate (beats/min) | 254±36 | 255±35 | 250 ± 24 | 248±24 |
| Stroke Volume (μl) | 169.0±17.6 | 228.1±16.0† | 121.5 ± 21.9 * | 93.2±21.6†‡ |
| Ejection Fraction (%) | 60±3 | 65±3† | 31 ± 5* | 23±5†‡ |
| LV end-diastolic pressure (mm Hg) | 5.5±1.1 | 6.0±0.7 | 14.2 ± 1.6 * | 18.3±1.2†‡ |
| LV end-systolic pressure (mm Hg) | 101±6 | 144±6† | 107 ± 5 | 145±13† |
| LV end-diastolic volume (μl) | 320.9±23.8 | 335.1±21.4 | 394.1 ± 17.5* | 402.0±19.4†‡ |
| LV end-systolic volume (μl) | 151.9±28.5 | 106.9±19.8† | 272.6 ± 16.6 * | 308.9±12.6†‡ |
| Maximum dV/dt (μl /sec) | 6,954±864 | 6,929±730 | 4,683 ± 335 * | 3,547±268†‡ |
| Time constant of relaxation (msec) | 9.7±0.6 | 9.6±0.7 | 16.0 ± 2.4 * | 23.0±2.7†‡ |
| EA (mm Hg/μl) | 0.60±0.06 | 0.63±0.04 | 0.91 ± 0.15 * | 1.63±0.34†‡ |
Values are means ± SD. n= number of rats.
LV, left ventricular; maximum dV/dt, the peak rate of mitral flow; EA, arterial elastance.
*
P <0.05, HF baseline vs. control baseline.
†
P <0.05, Ang-(1–12) vs. corresponding baseline value.
‡
p<0.05, Ang-(1–12)-induced changes after HF vs. Ang-(1–12)-induced changes in normal.