Appendix 3.
Levels of soluble factors in study group pre and post-PMC.
| Variables | Pre-PMC group | Post-PMC group | P-value |
|---|---|---|---|
| Growth factors | |||
| GM-CSF | 17 (13–21) | 14 (12–18) | 0.06 |
| G-CSF | 51 (33–77) | 39 (31–56) | 0.14 |
| VEGF | 23 (17–34) | 17 (16–24) | 0.03 |
| FGF basic | 24 (19–37) | 22 (17–29) | 0.01 |
| PDGF | 820 (199–1,810) | 314 (210–1,033) | 0.02 |
| Proliferative factors | |||
| IL-2 | 17 (13–23) | 14 (13–19) | 0.01 |
| IL-7 | 22 (20–23) | 19 (18–23) | 0.03 |
| IL-15 | 20 (19–27) | 20 (18–27) | 0.03 |
| Chemokines | |||
| CXCL10 | 1,280 (690–1,971) | 1,088 (625–1,815) | 0.05 |
| CCL2 | 171 (69–357) | 127 (48–324) | 0.20 |
| CCL3 | 375 (98–6,394) | 212 (83–1,513) | 0.06 |
| CCL4 | 1,265 (736–2,304) | 1,018 (576–1,586) | 0.16 |
| CCL11 | 2,533 (448–3,614) | 1,966 (301–2,971) | 0.01 |
| CCL5 | 2,574 (1,738–2,995) | 2,377 (1,732–3,004) | 0.40 |
| IL-8 | 65 (33–467) | 29 (25–58) | 0.14 |
| Cytokines | |||
| TNF-α | 22 (16–31) | 19 (14–27) | 0.10 |
| IL-10 | 16 (13–22) | 14 (12–24) | 0.88 |
| IL-5 | 18 (14–24) | 15 (13–20) | 0.01 |
| IL-9 | 42 (34–49) | 35 (30–40) | 0.10 |
| IL-1 β | 23 (18–26) | 17 (16–24) | 0.02 |
| IL-6 | 13 (13–18) | 12 (11–15) | 0.004 |
| IL-12p70 | 16 (14–18) | 14 (14–16) | 0.01 |
| IL-17 | 62 (29–93) | 40 (31–73) | 0.06 |
| IFN-γ | 23 (17–42) | 21 (17–37) | 0.13 |
| IL-1ra | 270 (155–1,057) | 282 (143–654) | 0.31 |
| IL-4 | 136 (49–178) | 99 (49–176) | 0.01 |
| IL-13 | 15 (13–18) | 14 (13–16) | 0.09 |
Data are presented as median and interquartile range (Q1–Q3). PMC, percutaneous mitral commissurotomy. Bold values represent statistically significant differences.