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. 2021 Jan 21;11:575255. doi: 10.3389/fmicb.2020.575255

FIGURE 2.

FIGURE 2

Transient burst of viral lytic gene expression in the pre-latent phase of EBV infection of Akata(–) cells. (A) Heat map showing the viral gene expression changes during EBV infection of Akata(–) cells. (B) Temporal change of viral gene expression in each kinetic lytic gene. The changes of respective genes and the mean values (black) are plotted. Viral gene expression kinetics are categorized into five groups: latent, immediate early, early, leaky late, and late (Djavadian et al., 2018). (C) Relative viral gene expression of latent, immediate early, early, leaky late, and late kinetics at 14 dpi. (D) Validation of viral gene expression by qRT-PCR. Viral gene expression was normalized to GAPDH expression. Results are presented as means ± SD of three independent experiments and are shown relative to gene expression at 2 dpi.