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. 2021 Feb 16;11(2):e041720. doi: 10.1136/bmjopen-2020-041720

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Participant timeline. *Visit 1 takes place in the MS centre to discuss the findings of the first MRI and by telephone through the study centre to clarify technical questions. **Visit 5 and visit 6 only in early recruited patients (flexible follow-up). MS, multiple sclerosis.