Table 1.

Assessments and measurement time points

Instrument	Measurement time points
	t−1	t0	V1	V2	V3	V4	V5*	V6*	tX
Month	−1	0	1	3	6	12	18*	24*	X
Eligibility screen	X
Informed consent	X
Demographic data	X
MRI		X		X	X	X	X	X
Clinical visit		X	X	X	X	X	X	X	X
Relapse history		X	X	X	X	X	X	X	X
Immunotherapy status		X	X	X	X	X	X	X	X
EDSS		X				X
RIKNO				X
CPS						X			X
Decision satisfaction									X
Patient activation		X				X
Emotional coping		X				X
Changes in empowerment						X
Expectancy			X
Readiness to change		X		X		X
HAQUAMS		X				X
EQ-5D-5L		X			X	X	X	X
HADS		X				X
GLTEQ		X				X
BSA		X				X
QHOD2		X		X		X
myfood24		X				X
Process evaluation	X	X	X	X	X	X	X	X
Health economic parameters		X			X	X	X	X

t₋₁=before enrolment; t₀=before allocation; V₁–V₆=post allocation (V₁=visit in month 1; V₂=visit in month 3; V₃=visit in month 6; V₄=visit in month 12; V₅=visit in month 18; V₆=visit in month 24); t_x=after reaching the primary endpoint.

*Only in early recruited PwMS.

BSA, Bewegungs- und Sportaktivität Fragebogen (Physical Activity, Exercise and Sport Questionnaire); CPS, Control Preference Scale; EDSS, Expanded Disability Status Scale; GLTEQ, Godin Leisure-Time Exercise Questionnaire; HADS, Hospital Anxiety and Depression Scale; HAQUAMS, Hamburg Quality of Life in Multiple Sclerosis Scale; PwMS, persons with multiple sclerosis; QHOD2, Questionnaire of Healthy Diet; RIKNO, Risk Knowledge in Relapsing Multiple Sclerosis.