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Role of non-canonical programmed cell death 1 (PD-1) signaling in tumorous Treg. PD-1 signaling inhibit proliferation and suppressive activity of tumorous Fr-II Tregs, while inhibiting IFN-γ production of tumorous Fr-III Tregs. In tumor, the major Treg population is Fr-II Treg. Thus, blockade of PD-1 signaling boost Fr-II Treg by promoting its proliferation and suppressive activity and potentially leads to hyperprogressive disease (HPD). IFN, interferon.
