Table 2.
Power estimates (5% type 1 error rate for each primary outcome measure)
| Standard deviation (log10) | Difference in mean log10 transformed outcome between trial arms | ||||||
| 0.08 | 0.10 | 0.12 | 0.14 | 0.16 | 0.18 | 0.20 | |
| 192 intensive PZQ vs 192 standard PZQ (Schistosoma mansoni infected only) | |||||||
| 0.3 | 65% | 83% | 94% | 98% | >99% | >99% | >99% |
| 0.4 | 42% | 59% | 75% | 87% | 94% | 98% | 99% |
| 0.5 | 29% | 42% | 56% | 69% | 80% | 88% | 94% |
| 0.6 | 21% | 31% | 42% | 53% | 65% | 75% | 83% |
Cells highlighted in grey correspond to >80% power; differences in mean log10 transformed outcome of 0.08, 0.10, 0.12, 0.14, 0.16, 0.18 and 0.20 are equivalent to geometric mean ratios for untransformed outcomes of 1.20, 1.26, 1.32, 1.38, 1.45, 1.51 and 1.59, respectively.
PZQ, praziquantel.