Table 4.

Comparison of different studies to find the beneficial effect of zinc supplementation

Study	Year of publication	Number of patients	Method of zinc supplementation and dose	Treatment regimen	Beneficial (yes/no)
Ertekin et al.[2]	2004	30	Zinc sulfate tablets 50 mg 3 times daily	Conventional RT	Yes
Lin et al.[10]	2006	100	Pro-Z powder 25 mg 2 to 4 times daily	Concurrent CT and RT	Yes
Lin et al.[9]	2010	100	Pro-Z powder 25 mg 2 to 4 times daily	Concurrent CT and RT	Yes
Watanabe et al.[30]	2010	31	Polaprezinc solution rinse and swallow	Concurrent CT and RT	Yes
Mosalaei et al.[23]	2010	58	Zinc sulfate tablets 220 mg 3 times daily	Conventional RT	Yes
Mehdipour et al.[11]	2011	30	10 ml of 0.2% zinc sulfate mouthwash 3 times daily	CT for leukemia patients	Yes
Mansouri et al.[15]	2012	60	Zinc sulfate tablets 220 mg twice daily	CT for bone marrow disorders	No
Gorgu et al.[24]	2013	40	Zinc C tablets 25 mg 4 times daily	Conventional RT	No
Sangthawan et al.[14]	2013	144	Zinc sulfate 50 mg tablets 3 times daily	Conventional RT	No
Moslemi et al.[12]	2014	40	Zinc sulfate 30 mg tablets 3 times daily	Concurrent CT and RT	Yes
Rambod et al.[13]	2018	86	Zinc sulfate 50 mg tablets 3 times daily	CT for leukemia patients	Yes
Shuai et al.[25] Meta-analysis	2019	162	Zinc sulfate tablets	Concurrent CT and RT	No

RT: Radiotherapy, CT: Chemotherapy