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Macamide 4 (100 mg/kg) was efficacious against LPS-induced inflammatory pain in rat. Scores are the means ± SEM reported as percent of baseline (normalized to 100%), calculated as the score × 100/baseline score. The median value of efficacy was statistically significant compared to the vehicle control (NEOBEE 1053) over a 6-h time-course (Kruskal-Wallis One Way Analysis of Variance on Ranks, α=0.05, *p ≤ 0.001, n=4/group).
