Table 1.
Antifungal susceptibility of otomycosis agents (Aspergillus species complex)
| Species | Antifungals | Minimum Inhibitory Concentration (µg/mL) |
Resistant (%) | %ECVa | |||
|---|---|---|---|---|---|---|---|
| MIC | MIC50 | MIC90 | MICGM | ||||
| Aspergillus niger complex (36) | Terbinafine | 0.0312-0.5 | 0.0625 | 0.5 | 0.10509 | - | ND |
| Caspofunginb | 0.0312-8 | 0.0312 | 4 | 0.12444 | 15 (41.7%) | 58.3% | |
| Fluconazole | 1-128 | 64 | 128 | 50.79683 | 10 (27.8%) | ND | |
| Itraconazole | 0.0312-2 | 0.5 | 1 | 0.39641 | 0 (0.0%) | 100% | |
| Miconazole | 0.25-4 | 0.25 | 2 | 0.39685 | - | ND | |
| Bifonazole | 0.0312-2 | 0.5 | 1 | 0.29671 | - | ND | |
| Econazole | 0.0625-0.5 | 0.0625 | 0.125 | 0.07577 | - | ND | |
| A. flavus complex (30) | Terbinafine | 0.0625-1 | 0.25 | 0.5 | 0.17678 | - | ND |
| Caspofunginb | 0.0312-8 | 8 | 8 | 3.24849 | 23 (76.7%) | 23.3% | |
| Fluconazole | 1-128 | 64 | 128 | 64 | 14 (46.7%) | ND | |
| Itraconazole | 0.0312-8 | 0.25 | 1 | 0.30777 | 1 (3.3%) | 96.7% | |
| Miconazole | 0.25-8 | 1 | 4 | 1.02337 | - | ND | |
| Bifonazole | 0.0312-8 | 2 | 8 | 1.58732 | - | ND | |
| Econazole | 0.0312-0.25 | 0.125 | 0.25 | 0.10389 | - | ND | |
| A. terreus complex (1) | Terbinafine | 0.25 | - | - | - | - | ND |
| Caspofunginb | 8 | - | - | - | 1 (100%) | 0.0% | |
| Fluconazole | 16 | - | - | - | 0 (0.0%) | ND | |
| Itraconazole | 0.25 | - | - | - | 0 (0.0%) | 100% | |
| Miconazole | 1 | - | - | - | - | ND | |
| Bifonazole | 0.5 | - | - | - | - | ND | |
| Econazole | 0.125 | - | - | - | - | ND | |
| A. nidulans complex (1) | Terbinafine | 1 | - | - | - | - | ND |
| Caspofunginb | 0.125 | - | - | - | 0 (0.0%) | 100% | |
| Fluconazole | 128 | - | - | - | 1 (100%) | ND | |
| Itraconazole | 0.125 | - | - | - | 0 (0.0%) | 100% | |
| Miconazole | 1 | - | - | - | - | ND | |
| Bifonazole | 2 | - | - | - | - | ND | |
| Econazole | 0.125 | - | - | - | - | ND | |
ECV: epidemiologic cutoff values, ND: not determined
a %MICs less than or equal to the ECVs (ECV=1-2 µg/ml for itraconazole, 0.06-0.12 µg/ml for caspofungin)
b Minimum effective concentration (MEC), MEC50, MEC90, and MECGM were calculated for organisms.