Table 2.

Association between muscle attenuation, thigh IMAT index, muscle attenuation and 6 min walk distance, gait speed and survival

6MWD	N	Change in 6MWD (m) per ½-SD decrease in thigh mean muscle attenuation	95% CI	P value	N	Change in 6MWD (m) per doubling in thigh IMAT index	95% CI	P value	N	Change in 6MWD (m) per ½-SD decrease in abdominal mean muscle attenuation	95% CI	P value
Unadjusted	276	−19	−25 to −13	<0.001	206	−10	−19 to −2	0.01	302	−18	−24 to −13	<0.001
Model 1*	275	−15	−21 to −10	<0.001	205	−12	−19 to −4	0.002	301	−14	−20 to −8	<0.001
Model 2†	275	−15	−21 to −10	<0.001	190	−13	−20 to −6	0.001	301	−14	−20 to −8	<0.001
Model 3‡	275	−13	−19 to −7	<0.001	190	−6	−16 to 3	0.18	301	−14	−20 to −7	<0.001
Survival	N	Sub-hazard distribution for death or delisting per ½-sD decrease in thigh mean muscle attenuation	95% CI	P value	N	Subhazard distribution for death or delisting per doubling in thigh IMAT index	95% CI	P value	N	Subhazard distribution for death or delisting per ½-sD decrease in abdominal mean muscle attenuation	95% CI	P value
Unadjusted	276	1.1	0.9 to 1.3	0.40	206	1.0	0.9 to 1.1	0.86	302	1.2	1.01 to 1.5	0.04
Model 1*	275	1.1	0.9 to 1.3	0.31	205	1.0	0.9 to 1.1	0.83	301	1.2	0.99 to 1.5	0.06
Model 2†	275	1.1	0.9 to 1.2	0.25	190	1.0	0.98 to 1.04	0.47	301	1.2	1.1 to 1.4	0.006
Model 3‡	275	1.1	0.96 to 1.2	0.21	190	1.0	0.8 to 1.4	0.89	301	1.3	1.2 to 1.4	<0.001

^*Adjusted for sex, age, forced vital capacity and diagnosis; centre as random effect in 6MWD models; standard errors clustered by centre in survival models.

^†Model 1+skeletal muscle index.

^‡Model 2+body mass index.

IMAT, intramuscular adipose tissue; 6MWD, 6 min walk distance.