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. Author manuscript; available in PMC: 2021 Feb 17.
Published in final edited form as: Cell Rep. 2021 Jan 26;34(4):108682. doi: 10.1016/j.celrep.2020.108682

Figure 7. H5N1 vaccine-elicited pAb response mimics natural infection and generates heterosubtypic immunity.

Figure 7.

(A) H5 HA (A/Indonesia/5/2005) with vulnerable sites (VSs) marked in yellow for VS1, red for VS2, dark pink for VS3, and light pink for VS4. Footprints of pAbs from all subjects at day 28 are outlined in black.

(B) Negative stain EM reconstruction of subject 43 pAbs in complex with recombinant H1 HA (A/Michigan/45/2015) at day 21. Stem specificity, blue.

(C) Subject 4, day 28 negative stain epitope landscape with broadly neutralizing antibodies docked into HA density. bnAb S139/1 (PDB 4GMS), orange; bnAb H5M9 (4MHH), pink; bnAbCR9114 (4FQI), blue.

See also Figure S7.