Table 1.
Demographics and Outcomes in Prospective COVID-19 Cohort
| Group | Fluvoxamine N = 65 | No Therapy N = 48 | P Valuea |
|---|---|---|---|
| Men | 50 (59%) | 35 (41%) | .66 |
| Age, years | 44 ± 15 | 43 ± 15 | .74 |
| Age >65 years | 5 (7%) | 2 (4%) | |
| Age 50–64 years | 17 (26%) | 15 (31%) | |
| Race/Ethnicity | .001 | ||
| Latino | 61 (94%) | 34 (71%) | |
| White, non-Hispanic | 3 (5%) | 13 (27%) | |
| African American | 1 (1.5%) | 0 (0%) | |
| Asian | 0 (0%) | 1 (2%) | |
| Chronic comorbidity | 16 (25%) | 18 (38%) | .15 |
| Diabetes | 11 (17%) | 4 (8%) | |
| Hypertension, treated | 11 (17%) | 17 (35%) | |
| Lung disease | 2 (3%) | 1 (2%) | |
| Days for PCR confirmation | 3.7 ± 1.3 | 3.4 ± 1.4 | .25 |
| Disease Status at Time of Testing | .064 | ||
| Asymptomatic | 25 (38%) | 28 (58%) | |
| Mild | 24 (37%) | 9 (19%) | |
| Moderateb | 16 (25%) | 11 (23%) | |
| Respiratory Rate | |||
| Day 1 | 17.7 ± 2.9 | 17.7 ± 3.4 | .95 |
| Day 7c | 12.9 ± 1.6 | 15.1 ± 4.1 | .001 |
| Hospitalized within 14 days | 0 | 6 | .005 |
| ICU care and/or Death | 0 | 2 | – |
| Symptoms at Day 14d | <.001 | ||
| None | 65 (100%) | 19 (40%) | |
| 1–3 | 0 (0%) | 15 (31%) | |
| 4–6 | 0 (0%) | 11 (23%) | |
| ≥7 | 0 (0%) | 3 (6%) |
Abbreviations: COVID-19, coronavirus disease 19; ICU, intensive care unit; PCR, polymerase chain reaction.
NOTE: Values are N (%) or mean (±standard deviation).
a P values are by Fisher’s exact test for categorical variables and independent t test for continuous variables.
bThose with moderate symptoms had reduction in activities of daily living.
cSix persons hospitalized had their day 1 value carried forward.
dSymptoms assessed at day 14 included the following: persistent anxiety (n = 19); difficulty concentrating, or memory challenges, or brain fog (n = 18); fatigue (n = 16); insomnia (n = 12); persistent body aches, muscle or joint pain (n = 10); headache (n = 9); dizziness (n = 9); inability to exercise (n = 6); chills or sweats (n = 5); persistent, intermittent nonproductive cough (n = 5); episodic chest tightness; pressure, or pain (n = 3); intermittent heart palpitations or tachycardia (n = 3); shortness of breath or difficulty breathing (n = 3); diarrhea (n = 0); elevated temperature (n = 0).