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. 2020 Dec 30;30(3):531–542. doi: 10.1002/pro.4014

TABLE 1.

Phenotypes caused by deletion of talin and kindlin and critically associated proteins

FA assembly b Cell function b
KO mice (day) a Number Size Spreading area Migration Ref.
Talin‐1 (2,541 aa) E8.5–9.5 Decrease Decrease Decrease Decrease 8 , 9 , 10
Kindlin‐2 (680 aa) E7.5 Decrease Decrease Decrease Decrease 8 , 11 , 12
Paxillin (591 aa) E9.5 Increase Decrease Decrease Decrease 12 , 13 , 14
Vinculin (1,134 aa) E10.5 Decrease Decrease Decrease Increase

15 , 16

ILK (452 aa) E5.5–6.5 Decrease c N/A d Decrease c Decrease 17 , 18 , 19
FAK (1,052 aa) E8.5 Increase N/A e Decrease Decrease 20 , 21 , 22
a

The embryonic day by which knock‐out (KO) mice display embryonic lethality.

b

In fibroblast system.

c

ILK‐null cells showed delayed spreading and formation of FAs.

d

See Ref. 18 for detailed analysis.

e

See Ref. 22 for detailed analysis.