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. 2021 Feb 4;17(2):e1009312. doi: 10.1371/journal.ppat.1009312

Fig 2. Mutational analysis of EBOV fusion-loop associated cavity reveals additional residues produce a MARV-like dose-response curve for toremifene.

Fig 2

Crystal structure of EBOV GP in complex with toremifene highlighting (A) essential residues for binding that produce a MARV-like dose response curve (teal) and (B) residues near the dimethylamine sidechain that play a dispensable role in binding (blue); (C-O) Dose-response curves for mutants at residues V66, L515, I38, L43, L184, I555, T520, R64, E100, N61, T519 and D522 compared to WT EBOV and WT MARV. All error bars represent s.d. from three independent experiments.