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. 2021 Feb 17;16(2):e0247169. doi: 10.1371/journal.pone.0247169

Fig 1. The expression of PAICS transcript in non-tumor mucosa, adenoma and colorectal carcinoma tissues.

Fig 1

PAICS expression in the FMU-RNA cohort based on quantitative RT-PCR (A), the MSK cohort based on Affymetrix microarray U133A (B), the CIT cohort based on Affymetrix microarray U133+2.0 (C), and the TCGA cohort based on RNA-seq (D). PAICS was upregulated in cancer tissues compared to those of normal mucosa (A-B), but showed a decreasing trend along with tumor progression from stage I through stage IV primary tumors (A-D). PAICS levels were further decreased in metastatic tumors (lung or liver metastasis) than those of primary tumors (A). ****P<0.0001, **P<0.01, *P<0.05.