Fig. 4.

Trio family protein mutations and phosphorylation sites. Specific locations of Trio mutations associated with various neurodevelopmental disorders. Interestingly, mutations to Trio cluster in distinct regions of the gene, many clustering around the area encoding the first GEF domain. Solid lines indicate missense mutations; dotted lines indicate nonsense mutations. For a full list of known mutations, see Table S1. BPD, bipolar disorder; ASD, autism spectrum disorder; ID, intellectual disability; DD, developmental delay; SCZ, schizophrenia. Domains of Trio are as in Fig. 1.